Determinants for successful deployment of clinical prediction models : a design science research in the Dutch healthcare sector

Whereas the promises of (predictive) analytics in healthcare are clear and extensively reported, the executive practicalities are not. Mapping the factors that have a hand in the implementation and continuation (i.e. deployment) of such projects improves the execution of prediction models and hence improves diagnostic and prognostic healthcare for patients. This research takes a design science approach to create an artifact aimed at successful deployment of clinical prediction models (CPMs). Through a literature review, various factors that play a role in the deployment of CPMs are categorized. Interviews with an extensive expert panel lead to the development of the CRISP-DM Deployment Extension for CPMs. Next to opinions on the importance of each factor, new in-sights are collected on related topics. A case study at a Dutch hospital allows for the testing of the artifact. A gap analysis is conducted, leading to a practical advice in terms of successful deployment. The research concludes with a proposed deployment strategy and a list of eight recommendations that can be considered the determinants for successful deployment of clinical prediction models

Circular RNAs in heart failure

Cardiovascular disease, and particularly heart failure, is still a serious health care issue for which novel treatments and biomarkers are needed. The RNA family comprises different subgroups, among which the small-sized microRNAs and the larger long non-coding RNAs have shown some potential to aid in moving personalized health care of heart failure patients a step forward. Here, members of the Cardiolinc network review the recent findings suggesting that the less well-known circular RNAs may constitute a novel reservoir of therapeutic targets and biomarkers of heart failure. The knowledge of the mode of biogenesis of circular RNAs will first be reported, followed by a description of different features that make these RNA molecules of interest for the heart failure community. The functions of circular RNAs in the heart will be described, with some emphasis given to their regulation in the failing heart. Circulating in the bloodstream, circular RNAs have appeared as potential biomarkers and recent findings associated with the use of circular RNAs as heart failure biomarkers will be discussed. Finally, some directions for future research will be provided